Integrating mass spectrometry with MD simulations reveals the role of lipids in Na(+)/H(+) antiporters

Na(+)/H(+) antiporters are found in all kingdoms of life and exhibit catalysis rates that are among the fastest of all known secondary-active transporters. Here we combine ion mobility mass spectrometry and molecular dynamics simulations to study the conformational stability and lipid-binding proper...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Landreh, Michael, Marklund, Erik G., Uzdavinys, Povilas, Degiacomi, Matteo T., Coincon, Mathieu, Gault, Joseph, Gupta, Kallol, Liko, Idlir, Benesch, Justin L. P., Drew, David, Robinson, Carol V.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5234078/
https://ncbi.nlm.nih.gov/pubmed/28071645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13993
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