Stress-impaired transcription factor expression and insulin secretion in transplanted human islets

Type 2 diabetes is characterized by insulin resistance, hyperglycemia, and progressive β cell dysfunction. Excess glucose and lipid impair β cell function in islet cell lines, cultured rodent and human islets, and in vivo rodent models. Here, we examined the mechanistic consequences of glucotoxic an...

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Pubblicato in:J Clin Invest
Autori principali: Dai, Chunhua, Kayton, Nora S., Shostak, Alena, Poffenberger, Greg, Cyphert, Holly A., Aramandla, Radhika, Thompson, Courtney, Papagiannis, Ioannis G., Emfinger, Christopher, Shiota, Masakazu, Stafford, John M., Greiner, Dale L., Herrera, Pedro L., Shultz, Leonard D., Stein, Roland, Powers, Alvin C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855919/
https://ncbi.nlm.nih.gov/pubmed/27064285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI83657
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