Stress-impaired transcription factor expression and insulin secretion in transplanted human islets

Type 2 diabetes is characterized by insulin resistance, hyperglycemia, and progressive β cell dysfunction. Excess glucose and lipid impair β cell function in islet cell lines, cultured rodent and human islets, and in vivo rodent models. Here, we examined the mechanistic consequences of glucotoxic an...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Dai, Chunhua, Kayton, Nora S., Shostak, Alena, Poffenberger, Greg, Cyphert, Holly A., Aramandla, Radhika, Thompson, Courtney, Papagiannis, Ioannis G., Emfinger, Christopher, Shiota, Masakazu, Stafford, John M., Greiner, Dale L., Herrera, Pedro L., Shultz, Leonard D., Stein, Roland, Powers, Alvin C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855919/
https://ncbi.nlm.nih.gov/pubmed/27064285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI83657
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