Stress-impaired transcription factor expression and insulin secretion in transplanted human islets

Type 2 diabetes is characterized by insulin resistance, hyperglycemia, and progressive β cell dysfunction. Excess glucose and lipid impair β cell function in islet cell lines, cultured rodent and human islets, and in vivo rodent models. Here, we examined the mechanistic consequences of glucotoxic an...

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書誌詳細
出版年:J Clin Invest
主要な著者: Dai, Chunhua, Kayton, Nora S., Shostak, Alena, Poffenberger, Greg, Cyphert, Holly A., Aramandla, Radhika, Thompson, Courtney, Papagiannis, Ioannis G., Emfinger, Christopher, Shiota, Masakazu, Stafford, John M., Greiner, Dale L., Herrera, Pedro L., Shultz, Leonard D., Stein, Roland, Powers, Alvin C.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 2016
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855919/
https://ncbi.nlm.nih.gov/pubmed/27064285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI83657
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