Function and regulation of TRPP2 ion channel revealed by a gain-of-function mutant

Mutations in polycystin-1 and transient receptor potential polycystin 2 (TRPP2) account for almost all clinically identified cases of autosomal dominant polycystic kidney disease (ADPKD), one of the most common human genetic diseases. TRPP2 functions as a cation channel in its homomeric complex and...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Arif Pavel, Mahmud, Lv, Caixia, Ng, Courtney, Yang, Lei, Kashyap, Parul, Lam, Clarissa, Valentino, Victoria, Fung, Helen Y., Campbell, Thomas, Møller, Simon Geir, Zenisek, David, Holtzman, Nathalia G., Yu, Yong
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855601/
https://ncbi.nlm.nih.gov/pubmed/27071085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1517066113
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