GABA-mediated tonic inhibition differentially modulates gain in functional subtypes of cortical interneurons

The binding of GABA (γ-aminobutyric acid) to extrasynaptic GABA(A) receptors generates tonic inhibition that acts as a powerful modulator of cortical network activity. Despite GABA being present throughout the extracellular space of the brain, previous work has shown that GABA may differentially mod...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Bryson, Alexander, Hatch, Robert John, Zandt, Bas-Jan, Rossert, Christian, Berkovic, Samuel F., Reid, Christopher A., Grayden, David B., Hill, Sean L., Petrou, Steven
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7022204/
https://ncbi.nlm.nih.gov/pubmed/31974304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1906369117
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