Function and regulation of TRPP2 ion channel revealed by a gain-of-function mutant

Mutations in polycystin-1 and transient receptor potential polycystin 2 (TRPP2) account for almost all clinically identified cases of autosomal dominant polycystic kidney disease (ADPKD), one of the most common human genetic diseases. TRPP2 functions as a cation channel in its homomeric complex and...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Arif Pavel, Mahmud, Lv, Caixia, Ng, Courtney, Yang, Lei, Kashyap, Parul, Lam, Clarissa, Valentino, Victoria, Fung, Helen Y., Campbell, Thomas, Møller, Simon Geir, Zenisek, David, Holtzman, Nathalia G., Yu, Yong
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2016
Sujets:
PNAS Plus
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855601/
https://ncbi.nlm.nih.gov/pubmed/27071085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1517066113
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires