Conductance of P2X(4) purinergic receptor is determined by conformational equilibrium in the transmembrane region

Ligand-gated ion channels are partially activated by their ligands, resulting in currents lower than the currents evoked by the physiological full agonists. In the case of P2X purinergic receptors, a cation-selective pore in the transmembrane region expands upon ATP binding to the extracellular ATP-...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Minato, Yuichi, Suzuki, Shiho, Hara, Tomoaki, Kofuku, Yutaka, Kasuya, Go, Fujiwara, Yuichiro, Igarashi, Shunsuke, Suzuki, Ei-ichiro, Nureki, Osamu, Hattori, Motoyuki, Ueda, Takumi, Shimada, Ichio
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855573/
https://ncbi.nlm.nih.gov/pubmed/27071117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600519113
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