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GPCR drug discovery: integrating solution NMR data with crystal and cryo-EM structures

The 826 G protein-coupled receptors (GPCRs) in the human proteome regulate key physiological processes, and thus have long been attractive as drug targets. With crystal structure determinations of more than 50 different human GPCRs during the last decade, an initial platform for structure-based rati...

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Detalhes bibliográficos
Publicado no:Nat Rev Drug Discov
Main Authors: Shimada, Ichio, Ueda, Takumi, Kofuku, Yutaka, Eddy, Matthew T., Wüthrich, Kurt
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6681916/
https://ncbi.nlm.nih.gov/pubmed/30410121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrd.2018.180
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