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GPCR drug discovery: integrating solution NMR data with crystal and cryo-EM structures
The 826 G protein-coupled receptors (GPCRs) in the human proteome regulate key physiological processes, and thus have long been attractive as drug targets. With crystal structure determinations of more than 50 different human GPCRs during the last decade, an initial platform for structure-based rati...
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| Publicat a: | Nat Rev Drug Discov |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6681916/ https://ncbi.nlm.nih.gov/pubmed/30410121 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrd.2018.180 |
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