Killer cell immunoglobulin-like receptor 3DL1 polymorphism defines distinct hierarchies of HLA class I recognition

Natural killer (NK) cells play a key role in immunity, but how HLA class I (HLA-I) and killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1) polymorphism impacts disease outcome remains unclear. KIR3DL1 (*001/*005/*015) tetramers were screened for reactivity against a panel of HLA-I molecules. Thi...

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Publicado en:J Exp Med
Autores principales: Saunders, Philippa M., Pymm, Phillip, Pietra, Gabriella, Hughes, Victoria A., Hitchen, Corinne, O’Connor, Geraldine M., Loiacono, Fabrizio, Widjaja, Jacqueline, Price, David A., Falco, Michela, Mingari, Maria Cristina, Moretta, Lorenzo, McVicar, Daniel W., Rossjohn, Jamie, Brooks, Andrew G., Vivian, Julian P.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2016
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854737/
https://ncbi.nlm.nih.gov/pubmed/27045007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20152023
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