Mutational and Structural Analysis of KIR3DL1 Reveals a Lineage-Defining Allotypic Dimorphism That Impacts Both HLA and Peptide Sensitivity

Killer Ig-like receptors (KIRs) control the activation of human NK cells via interactions with peptide-laden HLAs. KIR3DL1 is a highly polymorphic inhibitory receptor that recognizes a diverse array of HLA molecules expressing the Bw4 epitope, a group with multiple polymorphisms incorporating varian...

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Bibliografiske detaljer
Main Authors: O’Connor, Geraldine M., Vivian, Julian P., Widjaja, Jacqueline M., Bridgeman, John S., Gostick, Emma, Lafont, Bernard A. P., Anderson, Stephen K., Price, David A., Brooks, Andrew G., Rossjohn, Jamie, McVicar, Daniel W.
Format: Artigo
Sprog:Inglês
Udgivet: AAI 2014
Fag:
Molecular and Structural Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948114/
https://ncbi.nlm.nih.gov/pubmed/24563253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1303142
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