Mutational and Structural Analysis of KIR3DL1 Reveals a Lineage-Defining Allotypic Dimorphism That Impacts Both HLA and Peptide Sensitivity

Killer Ig-like receptors (KIRs) control the activation of human NK cells via interactions with peptide-laden HLAs. KIR3DL1 is a highly polymorphic inhibitory receptor that recognizes a diverse array of HLA molecules expressing the Bw4 epitope, a group with multiple polymorphisms incorporating varian...

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Bibliographische Detailangaben
Hauptverfasser: O’Connor, Geraldine M., Vivian, Julian P., Widjaja, Jacqueline M., Bridgeman, John S., Gostick, Emma, Lafont, Bernard A. P., Anderson, Stephen K., Price, David A., Brooks, Andrew G., Rossjohn, Jamie, McVicar, Daniel W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: AAI 2014
Schlagworte:
Molecular and Structural Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948114/
https://ncbi.nlm.nih.gov/pubmed/24563253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1303142
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