Mutational and Structural Analysis of KIR3DL1 Reveals a Lineage-Defining Allotypic Dimorphism That Impacts Both HLA and Peptide Sensitivity

Killer Ig-like receptors (KIRs) control the activation of human NK cells via interactions with peptide-laden HLAs. KIR3DL1 is a highly polymorphic inhibitory receptor that recognizes a diverse array of HLA molecules expressing the Bw4 epitope, a group with multiple polymorphisms incorporating varian...

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Main Authors: O’Connor, Geraldine M., Vivian, Julian P., Widjaja, Jacqueline M., Bridgeman, John S., Gostick, Emma, Lafont, Bernard A. P., Anderson, Stephen K., Price, David A., Brooks, Andrew G., Rossjohn, Jamie, McVicar, Daniel W.
Formáid: Artigo
Teanga:Inglês
Foilsithe: AAI 2014
Ábhair:
Molecular and Structural Immunology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948114/
https://ncbi.nlm.nih.gov/pubmed/24563253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1303142
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