The interaction of KIR3DL1*001 with HLA class I molecules is dependent upon molecular microarchitecture within the Bw4 epitope

The Killer cell Immunoglobulin-like Receptor 3DL1 (KIR3DL1) inhibits activation of Natural Killer (NK) cells upon interaction with Human Leukocyte Antigen (HLA) class I molecules such as HLA-B*57:01 which contain the Bw4 epitope spanning residues 77-83 (e.g. NLRIALR) and not with HLA allomorphs that...

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Publicado no:J Immunol
Main Authors: Saunders, Philippa M., Vivian, Julian P., Baschuk, Nikola, Beddoe, Travis, Widjaja, Jacqueline, O'Connor, Geraldine M., Hitchen, Corinne, Pymm, Phillip, Andrews, Daniel M., Gras, Stephanie, McVicar, Daniel W., Rossjohn, Jamie, Brooks, Andrew G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4282956/
https://ncbi.nlm.nih.gov/pubmed/25480565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402542
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