Killer cell immunoglobulin-like receptor 3DL1 polymorphism defines distinct hierarchies of HLA class I recognition

Natural killer (NK) cells play a key role in immunity, but how HLA class I (HLA-I) and killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1) polymorphism impacts disease outcome remains unclear. KIR3DL1 (*001/*005/*015) tetramers were screened for reactivity against a panel of HLA-I molecules. Thi...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Saunders, Philippa M., Pymm, Phillip, Pietra, Gabriella, Hughes, Victoria A., Hitchen, Corinne, O’Connor, Geraldine M., Loiacono, Fabrizio, Widjaja, Jacqueline, Price, David A., Falco, Michela, Mingari, Maria Cristina, Moretta, Lorenzo, McVicar, Daniel W., Rossjohn, Jamie, Brooks, Andrew G., Vivian, Julian P.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854737/
https://ncbi.nlm.nih.gov/pubmed/27045007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20152023
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