Immune activation of the host cell induces drug tolerance in Mycobacterium tuberculosis both in vitro and in vivo

Successful chemotherapy against Mycobacterium tuberculosis (Mtb) must eradicate the bacterium within the context of its host cell. However, our understanding of the impact of this environment on antimycobacterial drug action remains incomplete. Intriguingly, we find that Mtb in myeloid cells isolate...

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Bibliographische Detailangaben
Veröffentlicht in:J Exp Med
Hauptverfasser: Liu, Yancheng, Tan, Shumin, Huang, Lu, Abramovitch, Robert B., Rohde, Kyle H., Zimmerman, Matthew D., Chen, Chao, Dartois, Véronique, VanderVen, Brian C., Russell, David G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2016
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854729/
https://ncbi.nlm.nih.gov/pubmed/27114608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151248
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