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Functional Sites Induce Long-Range Evolutionary Constraints in Enzymes
Functional residues in proteins tend to be highly conserved over evolutionary time. However, to what extent functional sites impose evolutionary constraints on nearby or even more distant residues is not known. Here, we report pervasive conservation gradients toward catalytic residues in a dataset o...
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| Publicat a: | PLoS Biol |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4854464/ https://ncbi.nlm.nih.gov/pubmed/27138088 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002452 |
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