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Functional Sites Induce Long-Range Evolutionary Constraints in Enzymes

Functional residues in proteins tend to be highly conserved over evolutionary time. However, to what extent functional sites impose evolutionary constraints on nearby or even more distant residues is not known. Here, we report pervasive conservation gradients toward catalytic residues in a dataset o...

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Xehetasun bibliografikoak
Argitaratua izan da:PLoS Biol
Egile Nagusiak: Jack, Benjamin R., Meyer, Austin G., Echave, Julian, Wilke, Claus O.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2016
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854464/
https://ncbi.nlm.nih.gov/pubmed/27138088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002452
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