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Geometric Constraints Dominate the Antigenic Evolution of Influenza H3N2 Hemagglutinin
We have carried out a comprehensive analysis of the determinants of human influenza A H3 hemagglutinin evolution. We consider three distinct predictors of evolutionary variation at individual sites: solvent accessibility (as a proxy for protein fold stability and/or conservation), Immune Epitope Dat...
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| Publicado no: | PLoS Pathog |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4447415/ https://ncbi.nlm.nih.gov/pubmed/26020774 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004940 |
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