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Mistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution

The biological causes of selective pressures on coding-sequence evolution remain controversial, despite the surprising consistency of covariation between common measures of evolutionary change (substitution rates) and gene expression (mRNA levels, codon usage) across taxa. We carry out a unified ana...

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Bibliographic Details
Main Authors: Drummond, D. Allan, Wilke, Claus O.
Format: Artigo
Language:Inglês
Published: 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2696314/
https://ncbi.nlm.nih.gov/pubmed/18662548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.05.042
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