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Modeling coding-sequence evolution within the context of residue solvent accessibility

BACKGROUND: Protein structure mediates site-specific patterns of sequence divergence. In particular, residues in the core of a protein (solvent-inaccessible residues) tend to be more evolutionarily conserved than residues on the surface (solvent-accessible residues). RESULTS: Here, we present a mode...

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Bibliografiske detaljer
Main Authors: Scherrer, Michael P, Meyer, Austin G, Wilke, Claus O
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527230/
https://ncbi.nlm.nih.gov/pubmed/22967129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2148-12-179
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