Genetic Deficiency of Glutathione S-Transferase P Increases Myocardial Sensitivity to Ischemia-Reperfusion Injury

RATIONALE: Myocardial ischemia-reperfusion (I/R) results in the generation of oxygen-derived free radicals and the accumulation of lipid peroxidation-derived unsaturated aldehydes. However, the contribution of aldehydes to myocardial I/R injury has not been assessed. OBJECTIVE: We tested the hypothe...

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Détails bibliographiques
Publié dans:Circ Res
Auteurs principaux: Conklin, Daniel J., Guo, Yiru, Jagatheesan, Ganapathy, Kilfoil, Peter, Haberzettl, Petra, Hill, Bradford G., Baba, Shahid P., Guo, Luping, Wetzelberger, Karin, Obal, Detlef, Rokosh, D. Gregg, Prough, Russell A., Prabhu, Sumanth D., Velayutham, Murugesan, Zweier, Jay L., Hoetker, David, Riggs, Daniel W., Srivastava, Sanjay, Bolli, Roberto, Bhatnagar, Aruni
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854443/
https://ncbi.nlm.nih.gov/pubmed/26169370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.114.305518
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