Genetic Deficiency of Glutathione S-Transferase P Increases Myocardial Sensitivity to Ischemia-Reperfusion Injury

RATIONALE: Myocardial ischemia-reperfusion (I/R) results in the generation of oxygen-derived free radicals and the accumulation of lipid peroxidation-derived unsaturated aldehydes. However, the contribution of aldehydes to myocardial I/R injury has not been assessed. OBJECTIVE: We tested the hypothe...

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Publicado no:Circ Res
Main Authors: Conklin, Daniel J., Guo, Yiru, Jagatheesan, Ganapathy, Kilfoil, Peter, Haberzettl, Petra, Hill, Bradford G., Baba, Shahid P., Guo, Luping, Wetzelberger, Karin, Obal, Detlef, Rokosh, D. Gregg, Prough, Russell A., Prabhu, Sumanth D., Velayutham, Murugesan, Zweier, Jay L., Hoetker, David, Riggs, Daniel W., Srivastava, Sanjay, Bolli, Roberto, Bhatnagar, Aruni
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854443/
https://ncbi.nlm.nih.gov/pubmed/26169370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.114.305518
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