CARDIAC MYOCYTE-SPECIFIC EXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE PROTECTS AGAINST ISCHEMIA/REPERFUSION INJURY BY PREVENTING MITOCHONDRIAL PERMEABILITY TRANSITION

BACKGROUND: Inducible nitric oxide synthase (iNOS) is an obligatory mediator of the late phase of ischemic preconditioning (PC) but the mechanisms of its cardioprotective actions are unknown. In addition, it remains unclear whether sustained elevation of iNOS in myocytes provides chronic protection...

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Bibliographische Detailangaben
Hauptverfasser: West, Matthew B., Rokosh, Gregg, Obal, Detlef, Velayutham, Murugesan, Xuan, Yu-Ting, Hill, Bradford G., Keith, Rachel, Schrader, Jurgen, Guo, Yiru, Conklin, Daniel J., Prabhu, Sumanth D., Zweier, Jay L., Bolli, Roberto, Bhatnagar, Aruni
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2763350/
https://ncbi.nlm.nih.gov/pubmed/18936326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.108.791533
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