CARDIAC MYOCYTE-SPECIFIC EXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE PROTECTS AGAINST ISCHEMIA/REPERFUSION INJURY BY PREVENTING MITOCHONDRIAL PERMEABILITY TRANSITION

BACKGROUND: Inducible nitric oxide synthase (iNOS) is an obligatory mediator of the late phase of ischemic preconditioning (PC) but the mechanisms of its cardioprotective actions are unknown. In addition, it remains unclear whether sustained elevation of iNOS in myocytes provides chronic protection...

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Detalhes bibliográficos
Main Authors: West, Matthew B., Rokosh, Gregg, Obal, Detlef, Velayutham, Murugesan, Xuan, Yu-Ting, Hill, Bradford G., Keith, Rachel, Schrader, Jurgen, Guo, Yiru, Conklin, Daniel J., Prabhu, Sumanth D., Zweier, Jay L., Bolli, Roberto, Bhatnagar, Aruni
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2763350/
https://ncbi.nlm.nih.gov/pubmed/18936326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.108.791533
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