Glutathione S-transferase P protects against cyclophosphamide-induced cardiotoxicity in mice

High-dose chemotherapy regimens using cyclophosphamide (CY) are frequently associated with cardiotoxicity that could lead to myocyte damage and congestive heart failure. However, the mechanisms regulating the cardiotoxic effects of CY remain unclear. Because CY is converted to an unsaturated aldehyd...

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Veröffentlicht in:Toxicol Appl Pharmacol
Hauptverfasser: Conklin, Daniel J., Haberzettl, Petra, Jagatheesan, Ganapathy, Baba, Shahid, Merchant, Michael L., Prough, Russell A., Williams, Jessica D., Prabhu, Sumanth D., Bhatnagar, Aruni
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4430434/
https://ncbi.nlm.nih.gov/pubmed/25868843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2015.03.029
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