Glutathione S-transferase P deficiency induces glucose intolerance via JNK-dependent enhancement of hepatic gluconeogenesis

Hepatic glutathione S-transferases (GSTs) are dysregulated in human obesity, nonalcoholic fatty liver disease, and diabetes. The multifunctional GST pi-isoform (GSTP) catalyzes the conjugation of glutathione with acrolein and inhibits c-Jun NH(2)-terminal kinase (JNK) activation. Herein, we tested w...

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Bibliographic Details
Published in:Am J Physiol Endocrinol Metab
Main Authors: Ghosh Dastidar, Shubha, Jagatheesan, Ganapathy, Haberzettl, Petra, Shah, Jasmit, Hill, Bradford G., Bhatnagar, Aruni, Conklin, Daniel J.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6293160/
https://ncbi.nlm.nih.gov/pubmed/30153066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00345.2017
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