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Glutathione S-transferase P deficiency induces glucose intolerance via JNK-dependent enhancement of hepatic gluconeogenesis
Hepatic glutathione S-transferases (GSTs) are dysregulated in human obesity, nonalcoholic fatty liver disease, and diabetes. The multifunctional GST pi-isoform (GSTP) catalyzes the conjugation of glutathione with acrolein and inhibits c-Jun NH(2)-terminal kinase (JNK) activation. Herein, we tested w...
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| Udgivet i: | Am J Physiol Endocrinol Metab |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Physiological Society
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6293160/ https://ncbi.nlm.nih.gov/pubmed/30153066 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00345.2017 |
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