Cloning and Variation of Ground State Intestinal Stem Cells

Stem cells of the gastrointestinal tract, pancreas, liver, and other columnar epithelia collectively resist cloning in their elemental states. Here we demonstrate the cloning and propagation of highly clonogenic, “ground state” stem cells of the human intestine and colon. We show that derived stem c...

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Pubblicato in:Nature
Autori principali: Wang, Xia, Yamamoto, Yusuke, Wilson, Lane H., Zhang, Ting, Howitt, Brooke, Farrow, Melissa A., Kern, Florian, Ning, Gang, Hong, Yue, Khor, Chiea Chuen, Chevalier, Benoit, Bertrand, Denis, Wu, Lingyan, Nagarajan, Niranjan, Sylvester, Francisco A., Hyams, Jeffrey S., Devers, Thomas, Bronson, Roderick, Lacy, D. Borden, Ho, Khek Yu, Crum, Christopher P., McKeon, Frank, Xian, Wa
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4853906/
https://ncbi.nlm.nih.gov/pubmed/26040716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14484
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