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A CRISPR-based approach for targeted DNA demethylation
In mammalian cells, DNA methylation critically regulates gene expression and thus has pivotal roles in myriad of physiological and pathological processes. Here we report a novel method for targeted DNA demethylation using the widely used clustered regularly interspaced short palindromic repeat (CRIS...
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| Veröffentlicht in: | Cell Discov |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4853773/ https://ncbi.nlm.nih.gov/pubmed/27462456 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2016.9 |
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