Excessive UBE3A dosage impairs retinoic acid signaling and synaptic plasticity in autism spectrum disorders

The autism spectrum disorders (ASDs) are a collection of human neurological disorders with heterogeneous etiologies. Hyperactivity of E3 ubiquitin (Ub) ligase UBE3A, stemming from 15q11-q13 copy number variations, accounts for 1%-3% of ASD cases worldwide, but the underlying mechanisms remain incomp...

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Detalhes bibliográficos
Publicado no:Cell Res
Main Authors: Xu, Xingxing, Li, Chuanyin, Gao, Xiaobo, Xia, Kun, Guo, Hui, Li, Yali, Hao, Zijian, Zhang, Lei, Gao, Daming, Xu, Chenfan, Xu, Huatai, Xiong, Zhi-Qi, Qiu, Zilong, Mei, Ling, Xie, Xiaoduo, Ruan, Kangcheng, Hu, Ronggui
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2018
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752837/
https://ncbi.nlm.nih.gov/pubmed/29076503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2017.132
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