Structure and function of dioxygenases in histone demethylation and DNA/RNA demethylation

Iron(II) and 2-oxoglutarate (2OG)-dependent dioxygenases involved in histone and DNA/RNA demethylation convert the cosubstrate 2OG and oxygen to succinate and carbon dioxide, resulting in hydroxylation of the methyl group of the substrates and subsequent demethylation. Recent evidence has shown that...

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Bibliografiske detaljer
Udgivet i:IUCrJ
Main Authors: Dong, Cheng, Zhang, Heng, Xu, Chao, Arrowsmith, Cheryl H., Min, Jinrong
Format: Artigo
Sprog:Inglês
Udgivet: International Union of Crystallography 2014
Fag:
Feature Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224472/
https://ncbi.nlm.nih.gov/pubmed/25485134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2052252514020922
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