Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2

Polycomb repressive complex 2 (PRC2) silences gene expression through trimethylation of K27 of histone H3 (H3K27me3) via its catalytic SET domain. A missense mutation in the substrate of PRC2, histone H3K27M, is associated with certain pediatric brain cancers and is linked to a global decrease of H3...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Justin, Neil, Zhang, Ying, Tarricone, Cataldo, Martin, Stephen R., Chen, Shuyang, Underwood, Elizabeth, De Marco, Valeria, Haire, Lesley F., Walker, Philip A., Reinberg, Danny, Wilson, Jon R., Gamblin, Steven J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4853476/
https://ncbi.nlm.nih.gov/pubmed/27121947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11316
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