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Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2
Polycomb repressive complex 2 (PRC2) catalyzes histone H3K27 trimethylation (H3K27me3), a hallmark of gene silencing. Here we report the crystal structures of an active PRC2 complex of 170 kilodaltons from the yeast Chaetomium thermophilum in both basal and stimulated states, which contain Ezh2, Eed...
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| Publicado no: | Science |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5220110/ https://ncbi.nlm.nih.gov/pubmed/26472914 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aac4383 |
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