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mTORC1 directly phosphorylates and activates ERα upon estrogen stimulation

Breast cancer is the leading cause of cancer-related deaths among women. Approximately 75% of breast cancers are estrogen receptor α (ERα) positive, underscoring the dependence of cancer cells on estrogen for growth and survival. Patients treated with endocrine therapy often develop resistance, eith...

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Publicat a:Oncogene
Autors principals: Alayev, A, Salamon, R S, Berger, S M, Schwartz, N S, Cuesta, R, Snyder, R B, Holz, M K
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4853282/
https://ncbi.nlm.nih.gov/pubmed/26522726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.414
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