Structure and organization of heteromeric AMPA-type glutamate receptors

AMPA-type glutamate receptors (AMPARs), central mediators of rapid neurotransmission and synaptic plasticity, predominantly exist as heteromers of the GluA1-4 subunits. Here we report first AMPAR heteromer structures, which deviate substantially from existing GluA2 homomers. Crystal structures of th...

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Udgivet i:Science
Main Authors: Herguedas, Beatriz, García-Nafría, Javier, Cais, Ondrej, Fernández-Leiro, Rafael, Krieger, James, Ho, Hinze, Greger, Ingo H.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4852135/
https://ncbi.nlm.nih.gov/pubmed/26966189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad3873
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