Mapping the Interaction Sites between AMPA Receptors and TARPs Reveals a Role for the Receptor N-Terminal Domain in Channel Gating

AMPA-type glutamate receptors (AMPARs) mediate fast neurotransmission at excitatory synapses. The extent and fidelity of postsynaptic depolarization triggered by AMPAR activation are shaped by AMPAR auxiliary subunits, including the transmembrane AMPAR regulatory proteins (TARPs). TARPs profoundly i...

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Publicat a:Cell Rep
Autors principals: Cais, Ondrej, Herguedas, Beatriz, Krol, Karolina, Cull-Candy, Stuart G., Farrant, Mark, Greger, Ingo H.
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405707/
https://ncbi.nlm.nih.gov/pubmed/25373908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.09.029
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