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Influence of the TARP γ8-Selective Negative Allosteric Modulator JNJ-55511118 on AMPA Receptor Gating and Channel Conductance

AMPA-type gultamate receptors (AMPARs) mediate excitatory signaling in the brain and are therapeutic targets for the treatment of diverse neurological disorders. The receptors interact with a variety of auxiliary subunits, including the transmembrane AMPAR regulatory proteins (TARPs). The TARPs infl...

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Detalhes bibliográficos
Publicado no:Mol Pharmacol
Main Authors: Coombs, Ian D., Sexton, Craig A., Cull-Candy, Stuart G., Farrant, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: 2022
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615793/
https://ncbi.nlm.nih.gov/pubmed/35246481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/molpharm.121.000473
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