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Combined Treatment with Morphine and Δ(9)-Tetrahydrocannabinol in Rhesus Monkeys: Antinociceptive Tolerance and Withdrawal

Opioid receptor agonists are effective for treating pain; however, tolerance and dependence can develop with repeated use. Combining opioids with cannabinoids can enhance their analgesic potency, although it is less clear whether combined treatment alters opioid tolerance and dependence. In this stu...

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Pubblicato in:J Pharmacol Exp Ther
Autori principali: Gerak, L. R., France, C. P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4851324/
https://ncbi.nlm.nih.gov/pubmed/26937020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.231381
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