Low dose combination of morphine and Δ(9)-tetrahydrocannabinol circumvents antinociceptive tolerance and apparent desensitization of receptors

Morphine and Δ(9)-tetrahydrocannabinol (THC) produce antinociception via mu opioid and cannabinoid CB(1) receptors, respectively, located in central nervous system (CNS) regions including periaqueductal gray and spinal cord. Chronic treatment with morphine or THC produces antinociceptive tolerance a...

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Main Authors: Smith, Paul A., Selley, Dana E., Sim-Selley, Laura J., Welch, Sandra P.
Format: Artigo
Jezik:Inglês
Izdano: 2007
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040345/
https://ncbi.nlm.nih.gov/pubmed/17603035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2007.06.001
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