Low dose combination of morphine and Δ(9)-tetrahydrocannabinol circumvents antinociceptive tolerance and apparent desensitization of receptors

Morphine and Δ(9)-tetrahydrocannabinol (THC) produce antinociception via mu opioid and cannabinoid CB(1) receptors, respectively, located in central nervous system (CNS) regions including periaqueductal gray and spinal cord. Chronic treatment with morphine or THC produces antinociceptive tolerance a...

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Detalhes bibliográficos
Main Authors: Smith, Paul A., Selley, Dana E., Sim-Selley, Laura J., Welch, Sandra P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040345/
https://ncbi.nlm.nih.gov/pubmed/17603035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2007.06.001
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