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Maximum type I error rate inflation from sample size reassessment when investigators are blind to treatment labels
Consider a parallel group trial for the comparison of an experimental treatment to a control, where the second‐stage sample size may depend on the blinded primary endpoint data as well as on additional blinded data from a secondary endpoint. For the setting of normally distributed endpoints, we demo...
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| Publié dans: | Stat Med |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
John Wiley and Sons Inc.
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4851240/ https://ncbi.nlm.nih.gov/pubmed/26694878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.6848 |
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