The genome of chemorefractory chronic lymphocytic leukemia reveals frequent mutations of NOTCH1 and SF3B1

Next-generation whole-exome sequencing has revealed two novel genes, namely NOTCH1 and SF3B1, whose mutations predict poor outcome and preferentially associate with chemorefractory chronic lymphocytic leukemia (CLL). Analysis of 539 CLL cases documents that NOTCH1 mutations i) represent one of the m...

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Detalhes bibliográficos
Publicado no:Leukemia Suppl
Main Authors: Rossi, D, Rasi, S, Spina, V, Bruscaggin, A, Monti, S, Cresta, S, Famà, R, Deambrogi, C, Greco, M, Fangazio, M, Ciardullo, C, Piranda, D, Casaluci, G M, Messina, M, Giudice, I D, Chiaretti, S, Marinelli, M, Guarini, A, Foà, R, Gaidano, G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Proceedings Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4851197/
https://ncbi.nlm.nih.gov/pubmed/27175239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leusup.2012.16
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