Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness

The genetic lesions identified in chronic lymphocytic leukemia (CLL) do not entirely recapitulate the disease pathogenesis and the development of serious complications, such as chemorefractoriness. While investigating the coding genome of fludarabine-refractory CLL, we observed that mutations of SF3...

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Détails bibliographiques
Auteurs principaux: Rossi, Davide, Bruscaggin, Alessio, Spina, Valeria, Rasi, Silvia, Khiabanian, Hossein, Messina, Monica, Fangazio, Marco, Vaisitti, Tiziana, Monti, Sara, Chiaretti, Sabina, Guarini, Anna, Del Giudice, Ilaria, Cerri, Michaela, Cresta, Stefania, Deambrogi, Clara, Gargiulo, Ernesto, Gattei, Valter, Forconi, Francesco, Bertoni, Francesco, Deaglio, Silvia, Rabadan, Raul, Pasqualucci, Laura, Foà, Robin, Dalla-Favera, Riccardo, Gaidano, Gianluca
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2011
Sujets:
Clinical Trials and Observations
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245210/
https://ncbi.nlm.nih.gov/pubmed/22039264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-08-373159
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