Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia

Analysis of the chronic lymphocytic leukemia (CLL) coding genome has recently disclosed that the NOTCH1 proto-oncogene is recurrently mutated at CLL presentation. Here, we assessed the prognostic role of NOTCH1 mutations in CLL. Two series of newly diagnosed CLL were used as training (n = 309) and v...

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Main Authors: Rossi, Davide, Rasi, Silvia, Fabbri, Giulia, Spina, Valeria, Fangazio, Marco, Forconi, Francesco, Marasca, Roberto, Laurenti, Luca, Bruscaggin, Alessio, Cerri, Michaela, Monti, Sara, Cresta, Stefania, Famà, Rosella, De Paoli, Lorenzo, Bulian, Pietro, Gattei, Valter, Guarini, Anna, Deaglio, Silvia, Capello, Daniela, Rabadan, Raul, Pasqualucci, Laura, Dalla-Favera, Riccardo, Foà, Robin, Gaidano, Gianluca
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2012
Assuntos:
Clinical Trials and Observations
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257017/
https://ncbi.nlm.nih.gov/pubmed/22077063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-09-379966
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