NOTCH1 mutations in +12 chronic lymphocytic leukemia (CLL) confer an unfavorable prognosis, induce a distinctive transcriptional profiling and refine the intermediate prognosis of +12 CLL

Trisomy 12, the third most frequent chromosomal aberration in chronic lymphocytic leukemia (CLL), confers an intermediate prognosis. In our cohort of 104 untreated patients carrying +12, NOTCH1 mutations occurred in 24% of cases and were associated to unmutated IGHV genes (P=0.003) and +12 as a sole...

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Main Authors: Del Giudice, Ilaria, Rossi, Davide, Chiaretti, Sabina, Marinelli, Marilisa, Tavolaro, Simona, Gabrielli, Sara, Laurenti, Luca, Marasca, Roberto, Rasi, Silvia, Fangazio, Marco, Guarini, Anna, Gaidano, Gianluca, Foà, Robin
Formato: Artigo
Idioma:Inglês
Publicado: Ferrata Storti Foundation 2012
Assuntos:
Original Articles and Brief Reports
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3291600/
https://ncbi.nlm.nih.gov/pubmed/22207691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2011.060129
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