Identification of molecular and functional patterns of p53 alterations in chronic lymphocytic leukemia patients in different phases of the disease

We analyzed TP53 mutations in 483 chronic lymphocytic leukemia patients at different phases of the disease and found a higher incidence of mutations at the later phases and a distinctive mutation profile in each phase. p53 function evaluated by immunoblotting and flow cytometry after cell irradiatio...

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Hlavní autoři: Marinelli, Marilisa, Peragine, Nadia, Di Maio, Valeria, Chiaretti, Sabina, De Propris, Maria Stefania, Raponi, Sara, Tavolaro, Simona, Mauro, Francesca Romana, Giudice, Ilaria Del, Guarini, Anna, Foà, Robin
Médium: Artigo
Jazyk:Inglês
Vydáno: Ferrata Storti Foundation 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3659928/
https://ncbi.nlm.nih.gov/pubmed/22983585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2012.069906
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