Normal ABL1 is a tumor suppressor and therapeutic target in human and mouse leukemias expressing oncogenic ABL1 kinases

Leukemias expressing constitutively activated mutants of ABL1 tyrosine kinase (BCR-ABL1, TEL-ABL1, NUP214-ABL1) usually contain at least 1 normal ABL1 allele. Because oncogenic and normal ABL1 kinases may exert opposite effects on cell behavior, we examined the role of normal ABL1 in leukemias induc...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Dasgupta, Yashodhara, Koptyra, Mateusz, Hoser, Grazyna, Kantekure, Kanchan, Roy, Darshan, Gornicka, Barbara, Nieborowska-Skorska, Margaret, Bolton-Gillespie, Elisabeth, Cerny-Reiterer, Sabine, Müschen, Markus, Valent, Peter, Wasik, Mariusz A., Richardson, Christine, Hantschel, Oliver, van der Kuip, Heiko, Stoklosa, Tomasz, Skorski, Tomasz
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4850868/
https://ncbi.nlm.nih.gov/pubmed/26864341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-11-681171
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