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Membrane Cholesterol Modulates Superwarfarin Toxicity
Superwarfarins are modified analogs of warfarin with additional lipophilic aromatic rings, up to 100-fold greater potency, and longer biological half-lives. We hypothesized that increased hydrophobicity allowed interactions with amphiphilic membranes and modulation of biological responses. We find t...
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| Publicado no: | Biophys J |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4850322/ https://ncbi.nlm.nih.gov/pubmed/27119638 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.03.004 |
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