Modification of Salmonella Lipopolysaccharides Prevents the Outer Membrane Penetration of Novobiocin

Small hydrophilic antibiotics traverse the outer membrane of Gram-negative bacteria through porin channels. Large lipophilic agents traverse the outer membrane through its bilayer, containing a majority of lipopolysaccharides in its outer leaflet. Genes controlled by the two-component regulatory sys...

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Bibliographic Details
Published in:Biophys J
Main Authors: Nobre, Thatyane M., Martynowycz, Michael W., Andreev, Konstantin, Kuzmenko, Ivan, Nikaido, Hiroshi, Gidalevitz, David
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2015
Subjects:
Membranes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699856/
https://ncbi.nlm.nih.gov/pubmed/26682812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.10.013
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