SUMO-targeted ubiquitin ligase (STUbL) Slx5 regulates proteolysis of centromeric histone H3 variant Cse4 and prevents its mislocalization to euchromatin

Centromeric histone H3, CENP-A(Cse4), is essential for faithful chromosome segregation. Stringent regulation of cellular levels of CENP-A(Cse4) restricts its localization to centromeres. Mislocalization of CENP-A(Cse4) is associated with aneuploidy in yeast and flies and tumorigenesis in human cells...

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Bibliographic Details
Published in:Mol Biol Cell
Main Authors: Ohkuni, Kentaro, Takahashi, Yoshimitsu, Fulp, Alyona, Lawrimore, Josh, Au, Wei-Chun, Pasupala, Nagesh, Levy-Myers, Reuben, Warren, Jack, Strunnikov, Alexander, Baker, Richard E., Kerscher, Oliver, Bloom, Kerry, Basrai, Munira A.
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4850037/
https://ncbi.nlm.nih.gov/pubmed/26960795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-12-0827
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