PolySUMOylation by Siz2 and Mms21 triggers relocation of DNA breaks to nuclear pores through the Slx5/Slx8 STUbL

High-resolution imaging shows that persistent DNA damage in budding yeast localizes in distinct perinuclear foci for repair. The signals that trigger DNA double-strand break (DSB) relocation or determine their destination are unknown. We show here that DSB relocation to the nuclear envelope depends...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Horigome, Chihiro, Bustard, Denise E., Marcomini, Isabella, Delgoshaie, Neda, Tsai-Pflugfelder, Monika, Cobb, Jennifer A., Gasser, Susan M.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4840299/
https://ncbi.nlm.nih.gov/pubmed/27056668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.277665.116
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