SUMO-Targeted Ubiquitin Ligases (STUbLs) Reduce the Toxicity and Abnormal Transcriptional Activity Associated With a Mutant, Aggregation-Prone Fragment of Huntingtin

Cell viability and gene expression profiles are altered in cellular models of neurodegenerative disorders such as Huntington’s Disease (HD). Using the yeast model system, we show that the SUMO-targeted ubiquitin ligase (STUbL) Slx5 reduces the toxicity and abnormal transcriptional activity associate...

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Detalhes bibliográficos
Publicado no:Front Genet
Main Authors: Ohkuni, Kentaro, Pasupala, Nagesh, Peek, Jennifer, Holloway, Grace Lauren, Sclar, Gloria D., Levy-Myers, Reuben, Baker, Richard E., Basrai, Munira A., Kerscher, Oliver
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6154015/
https://ncbi.nlm.nih.gov/pubmed/30279700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2018.00379
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