Modulation of Polycystic Kidney Disease Severity by Phosphodiesterase 1 and 3 Subfamilies

Aberrant intracellular calcium levels and increased cAMP signaling contribute to the development of polycystic kidney disease (PKD). cAMP can be hydrolyzed by various phosphodiesterases (PDEs). To examine the role of cAMP hydrolysis and the most relevant PDEs in the pathogenesis of PKD, we examined...

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Dettagli Bibliografici
Pubblicato in:J Am Soc Nephrol
Autori principali: Ye, Hong, Wang, Xiaofang, Sussman, Caroline R., Hopp, Katharina, Irazabal, Maria V., Bakeberg, Jason L., LaRiviere, Wells B., Manganiello, Vincent C., Vorhees, Charles V., Zhao, Haiqing, Harris, Peter C., van Deursen, Jan, Ward, Christopher J., Torres, Vicente E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2016
Soggetti:
Brief Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4849815/
https://ncbi.nlm.nih.gov/pubmed/26374610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015010057
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