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Cyclic Nucleotide Signaling in Polycystic Kidney Disease
Increased levels of 3’–5’-cyclic adenosine monophosphate (cAMP) stimulate cell proliferation and fluid secretion in polycystic kidney disease (PKD). Since hydrolytic capacity of phosphodiesterases (PDE) far exceeds maximum rate of synthesis by adenylyl cyclases (AC), cellular levels of cAMP are more...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3725619/ https://ncbi.nlm.nih.gov/pubmed/19924104 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2009.438 |
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