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Cyclic Nucleotide Signaling in Polycystic Kidney Disease
Increased levels of 3’–5’-cyclic adenosine monophosphate (cAMP) stimulate cell proliferation and fluid secretion in polycystic kidney disease (PKD). Since hydrolytic capacity of phosphodiesterases (PDE) far exceeds maximum rate of synthesis by adenylyl cyclases (AC), cellular levels of cAMP are more...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3725619/ https://ncbi.nlm.nih.gov/pubmed/19924104 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2009.438 |
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