Modulation of Polycystic Kidney Disease Severity by Phosphodiesterase 1 and 3 Subfamilies

Aberrant intracellular calcium levels and increased cAMP signaling contribute to the development of polycystic kidney disease (PKD). cAMP can be hydrolyzed by various phosphodiesterases (PDEs). To examine the role of cAMP hydrolysis and the most relevant PDEs in the pathogenesis of PKD, we examined...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Ye, Hong, Wang, Xiaofang, Sussman, Caroline R., Hopp, Katharina, Irazabal, Maria V., Bakeberg, Jason L., LaRiviere, Wells B., Manganiello, Vincent C., Vorhees, Charles V., Zhao, Haiqing, Harris, Peter C., van Deursen, Jan, Ward, Christopher J., Torres, Vicente E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2016
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4849815/
https://ncbi.nlm.nih.gov/pubmed/26374610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015010057
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